AMPs are essential components of innate immunity, providing the first line of defense against oral microbial colonization and infection.63 Most AMPs have antimicrobial activity against Gram-negative and Gram-positive bacteria,63 fungi64 and viruses.65 AMPs are classified based on amino-acid composition, conformational structure and size.66 The most common AMPs expressed in the saliva are listed in Table 1 and described below. Here, ADSL is linked to infection.