The GEE model with adjustments for age, gender, and the prevalence of hypertension and type 2 diabetes mellitus in the dominant and additive models showed significant relations (P < 3.39 × 10− 7) of rs11543349 in OGFR to serum creatinine concentration and eGFR (Table 2 and Online Resource 4). Here, OGFR is linked to Hypertension.