However, the relation of these SNVs to CKD or hyperuricemia could not be found in the replication study, except for rs55975541 in CDC42BPG. In the longitudinal EWAS for the discovery cohort, the SNV in CDC42BPG was significantly (P = 3.7 × 10− 12) associated with the serum concentration of uric acid. Here, CDC42BPG is linked to hyperuricemia.