The common neuropathological hallmark of α-synucleinopathies, including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), is the deposition of aggregated α-synuclein (a-syn) within affected brain regions, paralleled by neuronal loss (Halliday et al. 2011). The gene discussed is SNCA; the disease is Parkinson disease.