MAPT and Alzheimer disease: On the other hand, AD cell model exhibited the decreased expression of CAV-1 (P < 0.05) and p-GSK-3βSer9 (P < 0.01) and the increased expression of p-GSK-3βTyr216 (P < 0.01), as well as the enhanced phosphorylation of Tau protein at sites of Thr231 and Ser396 (P < 0.01).