In the present study, pEGFP-C1-CAV1 transfection and shRNA-CAV1 gene silencing in hippocampal neuron cell model with AD subjected to exogenous Aβ1–42 induction were applied to uncover the molecular mechanisms of RSBFL for the prevention and treatment of AD and the improvement of learning and memory capacity through attenuating oxidative stress and alleviating free radical damage. Here, CAV1 is linked to Alzheimer disease.