For example, β‐lactams, muscle relaxants, and certain types of contrast media can bind to IgE as antigens, whereas anaphylaxis mediated by non‐steroidal anti‐inflammatory drugs is mostly caused by non‐allergic mechanisms.16 As a consequence of mast cell and basophil activation by any of the above mechanisms, they release more than 100 chemical mediators of anaphylaxis. This evidence concerns the gene IGHE and anaphylaxis.