Anaphylaxis mediated by immunoglobulin (Ig)E, IgG, complement, or immune complexes is defined as immune‐mediated anaphylaxis, as opposed to non‐allergic anaphylaxis (previously known as an anaphylactoid reaction).15 Immune‐mediated anaphylaxis is further divided into IgE‐ and non IgE‐mediated types. The gene discussed is IGHE; the disease is anaphylaxis.