PPARGC1A and sarcopenia: Interestingly, some of the effects elicited by supplementary Cr overlap with, and may reinforce, the positive ones induced by physical exercise (i.e., higher expression of PGC-1α and of muscle regulatory factors), and others (i.e., the ergogenic ones) do support physical training: on the whole, these peculiar traits are likely to give rise to a positive loop that, with regard to sarcopenia, suggests that supplementary Cr may positively interact with physical exercise.