In two concordant studies it was shown that the proximal tubular epithelial cells (PTEC) treated with TGF-β1 may repress E-cadherin and exhibit EMT associated morphological changes, whereas the cells administered with MSC-derived EVs may reverse the morphological changes by resuming the E-cadherin expression; allowing the protection of mice against renal failure (He et al., 2015; Wang et al., 2015a). The gene discussed is CDH1; the disease is Renal insufficiency.