IL18 and chronic obstructive pulmonary disease: In support, the inhibition of NLRP3 by means of Gly did not affect the levels of IL-18 from unstable COPD-derived PBMCs after Soot-E (Figure 4A), Soot-E/DMF (Figure 4B), NOC-E (Figure 4C), or NOC-ED (Figure 4D) exposure.