IL18 and chronic obstructive pulmonary disease: As shown in Figures S1A–C in Supplementary Material, both coronene and pyrene (10 pg/ml) significantly increased IL-18 release from PBMCs of non-smokers (Figure S1A in Supplementary Material), smokers (Figure S1B in Supplementary Material), and unstable COPD (Figure S1C in Supplementary Material) at 10 pg/ml corresponding to 6E−4 cm2, implying that the size of the particles was not as relevant as the nature of the particles.