The pharmacological inhibition of caspase-1 did not alter the levels of IL-18 from unstable COPD-derived PBMCs after Soot-E (Figure 4A), Soot-E/DMF (Figure 4B), NOC-E (Figure 4C), or NOC-ED (Figure 4D) exposure. Here, IL18 is linked to chronic obstructive pulmonary disease.