Other PTPs have a role in OL maturation and myelination; Ptpa loss increased OPC proliferation (52); Ptprz knock out mice did not recover from EAE as well as controls and remyelination in MS plaques was associated with an upregulation of PTPRZ (53); also, hypomyelination was observed in Ptpre knock out mice (19). The gene discussed is PTPRE; the disease is myeloid sarcoma.