Moreover, the impact of Caiap on ST infection seemed to depend on flagellin, since the virulence of the flagellin mutant strain (FliC/FljB) of ST (35) was not affected by Caiap (Figures 6E,F), while the increased larval resistance and caspase-1 activity to ST which overexpresses flagellin (FliCON) (36) were found to be Caiap-dependent (Figures 6E,F). Here, CASP1 is linked to infection.