DHX58 and viral infectious disease: Similarly, we detected a limited number of gene expression changes (31 DEGs) in B-cells 6 DPI (Figure 1A), which also enriched to GO terms associated with innate immune defense to viral infection (Figure 5A) and consisted primarily of ISGs, i.e., DHX58, GBP1, IFIT1–3, 5 (Figure 5B).