A large number of genes upregulated 6 DPI are important for inflammatory responses such as CXCL10, SERPING1, PPBP, IL8, CSF3R, IL1R1, MYD88, IRAK2, and NFKBIA. The increased expression of chemokines CCL2, CCL4L1, and CCL8 may be important for the recruitment of additional monocytes and DCs to sites of infection allowing ZEBOV to disseminate. This evidence concerns the gene IL1R1 and infection.