GNRH1 and Familial prostate cancer: This central role in regulation of reproduction has made the GnRH receptor a target for treatment of infertility and of sex steroid-dependent hyperplasias, including uterine fibroids, endometriosis and prostatic cancer, where gonadal steroid production is decreased by administration of GnRH antagonists or high doses of GnRH agonists, which downregulate receptor expression (3–5).