This is because astrocytes are known to play critical roles in the pathogenic process of EAE and MS, and our recent studies showed that astrocytes in the adult CNS, including cerebellar Bergmann glia, are activated by both inflammatory insults and imbalance of neural activity (via Kv3.1 deletion) (Jukkola et al., 2013). The gene discussed is KCNC1; the disease is myeloid sarcoma.