To determine the potential role of Kv3.1 in MS progression including inflammatory demyelination and axon degeneration, we induced monophasic chronic EAE in female Kv3.1 KO mice and WT littermates with myelin oligodendrocyte glycoprotein (MOG) peptide 35–55 as described before (Jukkola et al., 2012, 2013). This evidence concerns the gene MOG and myeloid sarcoma.