Nonetheless, upregulated Kv3.3 likely works together with other ion channels to alter axonal functions, such as several Ca2+- and Na+-permeable channels that were also upregulated in injured axons in EAE and MS lesions (Kornek et al., 2001; Craner et al., 2004; Vergo et al., 2011; Schattling et al., 2012). This evidence concerns the gene KCNC3 and myeloid sarcoma.