FOXP3 and Autoimmunity: Accordingly, genetically-determined alterations of Foxp3 are responsible for a severe disorder called “Immunodysregulation, polyendocrinopathy, enteropathy, X-linked” (IPEX) which clinically translates into autoimmune conditions affecting the gut (autoimmune enteritis), skin (atopic eczema), pancreas (diabetes type I) and thyroid (Michels and Gottlieb, 2010).