SERPINE1 and breast cancer: Given the role of ROS in the regulation of N-cadherin and SERPINE1 (involved in matrix remodelling and cell migration50,51) and the effects of ROS on hypoxia-induced activation of the pro-migratory receptor EGFR52,53, we sought to explore the effects of NAC on the migration of MDA-MB-468 breast cancer cells during hypoxia.