Along these lines, decreased activity of MMPs in urinary extracellular vesicles (UEVs) of DN patients in comparison to normoalbuminuric diabetic patients, was reported by Musante et al. 4, leading collectively to the conclusion that kidney damage is associated with reduced activity of MMP-2 and MMP-9 in diabetic kidney tissue. This evidence concerns the gene MMP2 and liver dysplastic nodule.