The ability of CAR to interfere with Nanog, Oct4, SOX2, CD44 and BMI1 expression is consistent with the effects of other natural compounds (e.g., adriamycin and diflourinated curcumin) to control the cancer stem cell bulk and the aggressiveness of glioma and pancreatic adenocarcinoma82,83. This evidence concerns the gene POU5F1 and central nervous system cancer.