Thus, CAR contributes to block the switch to a mesenchymal phenotype induced by the inflammatory microenvironment by reducing the aggressive cancer phenotype.The acquisition of stem-like properties is linked to the activation of several genes, such as CD44, BMI1, Nanog, Oct4, and SOX2, which are expressed in embryonic stem cells, cancer cells, and cancer stem cells. This evidence concerns the gene BMI1 and cancer.