Importantly, the two largest RCTs33,42 (n = 928 and n = 332) in overweight and obese adults were in participants without vitamin D deficiency (baseline 25(OH)D range = 56–136 nmol/L), and both trials reported increased CRP concentrations after one year of supplementation with 20,000–40,000 IU of cholecalciferol weekly33,42. Here, CRP is linked to vitamin D deficiency.