Interestingly, the perturbation of transcriptional control of these genes was also detected in resealed H4IIEC3 cells containing HF cytosol that had been prepared from a high-fat diet-induced obese mouse, but not in resealed cells containing ApoE cytosol that had been prepared from a mouse model of atherosclerosis, an ApoE-deficient mouse (Supplementary Fig. S2a and S2b). The gene discussed is APOE; the disease is atherosclerosis.