Furthermore, when capsaicin (a TRPV1 agonist that activates C and Aδ fibres) or mustard oil (a TRPA1 agonist) was injected into the neurogenic spots, the development of hypertension was blocked, which was not observed in the saline-treated group (treatment F(2, 8) = 32.474, P < 0.001, Partial Eta-Squared = 0.890; time F(12, 48) = 38.40, P < 0.001; interaction F(24, 96) = 3.774, P < 0.001, Partial Eta-Squared = 0.485; Fig. 2D). The gene discussed is TRPA1; the disease is hypertensive disorder.