1993, Eliasson et al., 2008; Wang and Thurmond 2009). Prior to fusion with the plasma membrane, the granules need to dock to the release site and undergo the process of granular priming to make them ready for release of their insulin cargo. Impaired priming has been suggested to underlie the absence of first‐phase insulin secretion in individuals with pre‐ and full‐blown diabetes (Eliasson et al. 2008). Here, INS is linked to diabetes mellitus.