CUL3 and pseudohypoaldosteronism type 2: 1996a,b). In contrast, NCC gain‐of‐function due to mutations in WNK kinases (Wilson et al. 2001) or in the E3 ubiquitin ligase Cullin 3 or its adaptor protein Kelch‐like‐3 (Boyden et al. 2012) cause Gordon syndrome, also known as Familial Hyperkalemic Hypertension (Fhht), or pseudohypoaldosteronism type II.