2000), SPAK knockout and inactive SPAK knock‐in mice recapitulate Gitelman's phenotype (Rafiqi et al. 2010; Yang et al. 2010a; McCormick et al. 2011; Grimm et al. 2012). In contrast, constitutively active SPAK mice show characteristics of Gordon's syndrome (Grimm et al. 2017). Similarly, WNK4 knockout mice exhibited a mild Gitelman‐like phenotype (Castañeda‐Bueno et al. 2012), whereas a Gordon syndrome‐like phenotype is observed in mice with WNK4 gain‐of‐function (Lalioti et al. 2006; Yang et al. 2010a; Chiga et al. 2011; Chowdhury et al. 2013). Here, STK39 is linked to Gordon syndrome.