SNCA and Parkinson disease: Other MMP3-produced C-terminally truncated peptides of α-synuclein (aa 1–78, 1–91 and 1–93) have been reported under stress conditions, with aa 1–93 being implicated in dopamine neuronal loss in substantia nigra, suggesting that overexpression of the fragments could have a significant impact in Parkinson's disease (68).