Interestingly, microvesicles generated from activated/apoptotic human T lymphocytes have also been found to contain Shh naturally, and when administered to mice receiving angiotensin II, they were found to revert hypertension and endothelial dysfunction through a mechanism associated with Shh-induced production of nitric oxide, and by decreasing levels of oxidative stress (Marrachelli et al., 2013). This evidence concerns the gene SHH and endothelial dysfunction.