The multivariate analysis subsequently demonstrated that high Nav1.5 expression (HR = 2.738; 95% CI 1.100–6.819; P = 0.030) and lymph node metastasis (HR = 2.633; 95% CI 1.632–4.248; P < 0.001) were prognostic factors for low 5-year DFS rate. The gene discussed is SCN5A; the disease is metastatic malignant neoplasm in the lymph nodes.