As shown in Table 2, univariate analysis revealed that high Nav1.5 expression (HR = 2.504; 95% CI 1.007–6.227; P = 0.048), lymph node metastasis (HR = 2.524; 95% CI 1.566–4.070; P < 0.001), and preoperative CEA > 5 ng/mL (HR = 1.726; 95% CI 1.049–2.841; P = 0.032) were associated with low 5-year DFS rate. The gene discussed is SCN5A; the disease is metastatic malignant neoplasm in the lymph nodes.