In addition, Nav1.5 expression (HR = 4.653; 95% CI 1.131–19.142; P = 0.033) and lymph node metastasis (HR = 2.232; 95% CI 1.309–3.808; P = 0.003) remained the prognostic factors for 5-year DFS in patients with high ER-β expression colon cancer (Table 3). Here, ESR2 is linked to metastatic malignant neoplasm in the lymph nodes.