AGT and neoplasm: For example, Bouquet et al. showed adenovirus-mediated Agt overexpression inhibited tumor growth in preestablished human MDA-MB-231 mammary carcinomas in nude mice compared to controls and blocked tumorigenicity and pulmonary metastases of MDA-MB-231 and murine melanoma B16F10 cells when they were injected into C57BL/6 mice [38].