In a similar study, Ridder et al. report that endothelial deletion of Tak1, a component of the IL-1β signaling cascade, using the Slco1c1-CreERT2 line reduced the febrile and lethargic responses to intravenous IL-1β without affecting anorexia, weight loss, or corticosterone production [17]. Here, IL1B is linked to Anorexia.