Whereas, all the previous studies (Table 2) did not detect similar correlation except Ishikawa, Kitayama and Nagawa [31] who reported that strong leptin immunostaining is only associated with poor survival; Garofalo and associates [33] associated leptin immunostaining only with high grade tumors; Jeong and colleagues [39] linked leptin expression with histotype of breast cancer; and Colbert and coworkers [40] stated significant relationship with triple negative breast carcinoma. The gene discussed is LEP; the disease is triple-negative breast carcinoma.