Since keratinocytic Rxrαep−/− mutant mice formed spontaneous and acute neonatal UVB-induced melanocytic lesions relative to control mice with functional RXRα, our next aim was to understand if removal of keratinocytic Rxrα also leads to phenotypic changes in the normal skin adjacent to the tumor that increases susceptibility to melanomas. The gene discussed is RXRA; the disease is melanoma.