In order to understand what effects does loss of keratinocytic Rxrα have on metastasis of spontaneous and UVB induced melanomas, the axillary and inguinal draining lymph nodes (LNs) from Rxrαep−/−|Cdk4R24C/R24C|Tyr-NRASQ61K mice were analyzed for the presence of invasive melanocytes and compared them with lymph nodes from RxrαL2/L2|Cdk4R24C/R24C|Tyr-NRASQ61K (control) mice. This evidence concerns the gene RXRA and melanoma.