There was a higher degree of malignancy in melanomas from the trigenic Rxrαep−/− mouse line, where we observed a higher number of TYRP1-expressing melanoma cells invading into draining lymph nodes in RXRαep−/−|Tyr-NRASQ61K|Cdk4R24C/R24C mice with increased drainage seen in the UVB treated mice. Here, TYRP1 is linked to melanoma.