According to Mavoungou et al. [30,33], the mechanism underlying NK cells cytotoxicity in Plasmodium falciparum malaria, is the recognition of the DBL1α domain of the parasitic antigen PfEMP1 by the NKp30 activating receptor, resulting in parasitized red blood cells lysis. The gene discussed is NCR3; the disease is Plasmodium falciparum malaria.