To evaluate whether SOX9 protein expression was associated with either clinico-pathological parameters or outcome of patients with HCC, we correlated immunohistochemical SOX9 staining results with tumour stage, age, tumour grade, sex and presence of inclusion bodies, Mallory-denk bodies (MDB), intrahepatic B cells (IHB) or cirrhosis. This evidence concerns the gene SOX9 and hepatocellular carcinoma.