In addition, our data indicated that diabetes promotes renal cell necrosis through the alteration of the expression of heat shock protein family A (Hsp70) Member 5 (also known as 78 kDa glucose-regulated protein), superoxide dismutase 2, heme oxygenase 1, peroxiredoxin 3, kininogen, peroxisome proliferator-activated receptor gamma (PPARγ) and calbindin 1. The gene discussed is HSPA5; the disease is diabetes mellitus.