GCG and type 2 diabetes mellitus: The decrement in the ratio glucagon/GLP-1 by IL-6 in the alpha cell under hyperglycemic conditions, if taking place during type 2 diabetes pathogenesis in the islet enviorement could produce a reduction in beta cell apoptosis, a better insulin response to glucose by the beta cell, and increment in the alpha cell mass and maybe a higher rate of transdifferentiation from alpha to beta cell.