JAK1 and colorectal carcinoma: In colon adenocarcinoma (COAD), 8/151 (5.3%) MSS, 1/42 (2.4%) MSI-L, and 8/45 (17.8%) MSI-H samples had a frameshift in JAK1, which narrowly met the cutoff for statistical significance due to the large number of JAK1 alterations in MSS COAD samples (Fig 2F, P = 0.0126, Fisher’s exact test); in the FMI data set we did not observe any JAK1 frameshifts in MSS CRC samples.