Some of these regulators have been already associated with different forms of ischemia (e.g. Creb[58], Stat1[59], Bcl6[60], miR-122[61], miR-21[62], miR-214[63], miR-493[64]) while others have not (e.g. Maf, Nptx1, Lef1, miR-290, miR-297, miR-466). The gene discussed is LEF1; the disease is ischemia.