Some regulators that have been associated with ischemia and the mediation analysis revealed how they support each other in some cases but oppose each other in other cases include miR-122, Creb1 and miR-493, Stat1. Other regulators like miR-297, Maf, and miR-297, Nptx1 have not been associated with ischemia yet. This evidence concerns the gene CREB1 and ischemia.