Hence, if hOGG1 Ser326Cys, ITGA2 C807T and XPD Lys751Gln polymorphisms from the current study are verified to be valid diagnostic markers for NPC patients, the possibility exists for customizing screening modalities for high risk individuals, such as those with a family history of NPC. This evidence concerns the gene OGG1 and nasopharyngeal carcinoma.