Haplotype analysis using SNPStats software revealed that allele combination CGC (XPD-Gln751/hOGG1-Cys326/ITGA2-C807) (OR = 2.20, 95% CI = 1.06–4.58) conferred higher risk of NPC using haplotype AGC as reference. This evidence concerns the gene ERCC2 and nasopharyngeal carcinoma.