CEBPD has been suggested to positively regulated peroxisome proliferator-activated receptor-γ (PPARγ) transcription and protein expression in vascular smooth muscle cells and cancer cells.37, 61, 62 Moreover, the activation of PPARγ could suppress protein expression and transcription of CEBPD via the inactivation of signal transducer and activator of transcription 3 in vascular smooth muscle cells.61 These findings implied that CEBPD could be negatively autoregulated following PPARγ activation. The gene discussed is STAT3; the disease is cancer.