APA is regulated by changes in the activity and/or expression of key components of the cleavage and polyadenylation complex, which often cooperate with accessory RNA binding proteins (RBPs) that bind elements located near the regulated PAS.24 Some of these RBPs, like Sam68 and hnRNPH, are often upregulated in human cancers and can suppress or enhance recognition of cryptic PASs depending on the context.26, 27Notably, localization and function of Sam68,28 as well as many other RBPs,18, 29 is regulated upon genotoxic stress. This evidence concerns the gene KHDRBS1 and cancer.