CASP1 and colitis: NLRP6 is reported to influence the composition of the microbial ecology, with Nlrp6, il18, Asc, and Casp1-deficient mice developing a colitis-forming microbiota dominated by TM7 and Prevotellaceae (Bacteroidetes phyla) species [111]; however, these results have been refuted by further work using microbial phylogenetic analyses of littermate-controlled experiments [113].