AIF1 and Parkinson disease: We also find some individual cases where inflammation shows regional specificity, both by MEs and using microglial immunohistochemical labeling with IBA1 (Figure 4D). This is not unexepcted, as several diseases show region-specific inflammatory responses: for example, the substantia nigra pars compacta is particularly susceptible to neurodegeneration due to inflammation in Parkinson's disease (Ji et al., 2008).