Among individuals with dementia, pathological phosphorylated tau (pTau) and amyloid beta (Aβ) pathology findings are actually lower in the 90+ year old age group than in the 60–80 year old group (Haroutunian et al., 2008), whereas other neuropathological conditions such as Lewy bodies and hippocampal sclerosis were only identified in individuals with dementia (Corrada et al., 2012). This evidence concerns the gene MAPT and dementia.