TPX2 and cancer: Both over- and under-expression of TPX2 perturb MT organization, leading to genomic instability, and mutations in TPX2 are correlated with high metastasis frequency in cancer patients (Aguirre-Portolés et al., 2012; Carter et al., 2006; Gruss et al., 2002; Pérez de Castro and Malumbres, 2012).