PLN and familial dilated cardiomyopathy: Other studies have also highlighted that loss of MLP leads to perturbation in intracellular calcium handling and excitation–contraction coupling and that a double knockout of MLP and Phospholamban, which regulates sarcoplasmic reticulum calcium intake, rescues the DCM phenotype (Esposito et al. 2000; Kemecsei et al. 2010; Kuhn et al. 2012; Minamisawa et al. 1999, Su et al. 2001).