In this review we discuss selected examples of cardiomyopathy genes (TTN, FHL1, CSRP3, FLNC and PLN; see Table 1 and Fig. 1) which, based on their known biological functions and the (limited) functional work on the disease-causing pathogenic variants, have been shown to have important signalling functions in the heart. The gene discussed is PLN; the disease is cardiomyopathy.