Furthermore, Golden-Mason et al. noticed, that, activated phenotype of NK cells was not reversed by successful IFN-alpha-based therapy and was expressed as greater lymphokine-associated killing activity, viral control and degranulation [22] Moreover, antiviral treatment with IFN-alpha ribavirin was found to restore the activity of NK cells increasing the frequency of CD56 (bright) NK cells in CHC patients that achieved SVR [23]. The gene discussed is NCAM1; the disease is cryohydrocytosis.