It is interesting to note that BIO can activate Gli1 transcription in human breast cancer cells (Das et al., 2013), and GSK3 is known to silence Hh signaling by phosphorylating the Drosophila GLI homolog, Cubitus interruptus (Ci) following priming by PKA (Jia et al., 2002). Here, GLI1 is linked to breast carcinoma.