Furthermore, an active form of NeuroD1 in pancreas, phospho-NeuroD1 (p-NeuroD1) protein expression was decreased significantly in the F2-HF as compared with that in the F2-SC (0.66 ± 0.20 versus 0.31 ± 0.04, P = 0.040; Fig. 4). This evidence concerns the gene NEUROD1 and hydrops fetalis.