PDX1 and hydrops fetalis: Consequently, Pdx1 protein expression was decreased in the F2-HF as compared with that in the F2-SC (1.25 ± 0.33 versus 0.56 ± 0.21, P = 0.036; Fig. 4); NeuroD1 protein expression was slightly reduced in the F2-HF (0.68 ± 0.13 versus 0.56 ± 0.09, P = 0.278; Fig. 4).