After removing, seventy-three articles potentially met the inclusion criteria for eligibility, and 63 were excluded for the reasons as follows: not relevant (n = 46), no genotyping for PRSS1 (n = 7), no genotyping for p.R122H (n = 6), recurrent AP (n = 3), and autoimmune pancreatitis (n = 1). This evidence concerns the gene PRSS1 and alkaline phosphatase measurement.