In contrast to the unknown disease-related autoreactive T cells, many autoantibodies have been identified in patients with pSS, including anti-SSA/Ro and anti-SSB/La autoantibodies, rheumatoid factor, anti-nuclear antibody, anti-muscarinic type 3 acetylcholine receptors (M3R), and anti-α fodrin antibodies (3). Here, CALR is linked to peeling skin syndrome.