The use of ASA (weakly more selective for COX-1 than COX-2), CEL (COX-2-specific inhibitor) and indomethacin (non-selective inhibitor of COX-1 and COX-2) increases mortality and parasitemia (in peripheral blood and cardiac tissue), regardless of the mouse model or T. cruzi strain used (Celentano et al., 1995; Hideko Tatakihara et al., 2008). Here, PTGS1 is linked to parasitic infectious disease.