For this purpose, the objective of the present study is to evaluate, in an integrated view, the central and peripheral expression of genes involved in the transport (Slc16a2 and Slc16a10), metabolism (Dio1, Dio2, and Dio3) and action (Thra and Thrb) of thyroid hormones in murine models of NTIS induced by fasting or cecal ligation puncture (CLP)-induced sepsis. Here, DIO1 is linked to Sepsis.