PHLPP1 and neoplasm: For example, MicroRNA-30b can function as a tumor suppressor in CRC by targeting KRAS, PIK3CD and BCL2 [17], while MicroRNA-224, a tumor promoter, targets PHLPP1 and PHLPP2 [18], sustains Wnt/β-catenin signaling and promotes aggressive phenotype of CRC [19].